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UID:20250713T094915EDT-6276vzNhtV@132.216.98.100
DTSTAMP:20250713T134915Z
DESCRIPTION:How is cell diversity generated during development?\n\nGary Bad
 er\, University of Toronto\n	Tuesday January 25\, 12-1pm\n	Zoom Link: https:
 //mcgill.zoom.us/j/85428056343\n\nAbstract: Cell cycle duration changes dr
 amatically during development\, starting out fast to generate cells quickl
 y and slowing down over time as the organism matures. The cell cycle can a
 lso act as a transcriptional filter to control the expression of long gene
  transcripts\, which are partially transcribed in short cycles. Using math
 ematical simulations of cell proliferation\, we identify an emergent prope
 rty that this filter can act as a tuning knob to control gene transcript e
 xpression\, cell diversity\, and the number and proportion of different ce
 ll types in a tissue. Our predictions are supported by comparison to singl
 e-cell RNA-seq data captured over embryonic development. Additionally\, ev
 olutionary genome analysis shows that fast-developing organisms have a nar
 row genomic distribution of gene lengths while slower developers have an e
 xpanded number of long genes. Our results support the idea that cell cycle
  dynamics may be important across multicellular animals for controlling ge
 ne transcript expression and cell fate.\n
DTSTART:20220125T170000Z
DTEND:20220125T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Gary Bader
URL:/qls/channels/event/qls-seminar-series-gary-bader-
 336047
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