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UID:20250516T003248EDT-5672KlmdIk@132.216.98.100
DTSTAMP:20250516T043248Z
DESCRIPTION:Understanding cellular polarity and adhesion dynamics involved 
 in cell motility using spatiotemporal models\n\nAnmar Khadra (ºÃÉ«TVl Unive
 rsity)\n	Tuesday April 30\, 12-1pm\n	Montreal Neurological Institute\, deGra
 ndpre Communications Centre\n\nAbstract: Cellular movement plays important
  roles in many (patho)physiological processes\, such as immune cell respon
 se\, growth of neuronal axons and cancer. The regulation of this movement 
 depends on the interaction of several key proteins implicated in the devel
 opment of cellular polarity (consisting of a front and a back) and the for
 mation of protein complexes called adhesions. Adhesions anchor the cell to
  its substrate\, allowing it to migrate. In CHO cells\, three classes of a
 dhesion can be identified based on size and dynamic properties: nascent ad
 hesions\, focal complexes and focal adhesions. When cells extends forward 
 at the front\, nascent adhesions assemble and anchor the leading edge to t
 he substrate\, while focal adhesions at the back disassemble\, allowing de
 tachment\, retraction and forward movement. The dynamics of these processe
 s are controlled by a number of regulatory factors\, occurring on both cel
 l-wide and adhesion-level scales. The coordination of these regulatory fac
 tors is complex\, but insights into their dynamics can be gained from the 
 use of mathematical/biophysical modeling techniques which integrate many o
 f these components together. In this talk\, I will present our recently de
 veloped molecularly-explicit and mechanosensitive models of cell polarity 
 and adhesion dynamics to explore how local regulation of key adhesion prot
 eins (including paxillin\, rho family of GTPases and integrin) produce cel
 l-wide polarization and nascent adhesion assembly/disassembly. The dynamic
 s associated with various parameter regimes will be presented and insights
  into the mechanisms regulating adhesion dynamics will be provided.\n
DTSTART:20190430T160000Z
DTEND:20190430T170000Z
LOCATION:deGrandpre Communications Centre\, Montreal Neurological Institute
 \, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Seminar Series in Quantitative Life Sciences and Medicine
URL:/qls/channels/event/seminar-series-quantitative-li
 fe-sciences-and-medicine-296456
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