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UID:20250717T113656EDT-6792gcj7jj@132.216.98.100
DTSTAMP:20250717T153656Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at the MNI and ºÃÉ«TVl Universit
 y.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, click 
 here\n\n\nIain Clark\n\nAssistant Professor\, Bioengineering\, UC Berkeley
 \, USA\n\nHost: jo.stratton [at] mcgill.ca (Jo Anne Stratton)\n\nAbstract:
  Central nervous system (CNS)-resident astrocytes and microglia interact t
 o regulate pro-inflammatory programs that drive neurodegenerative diseases
 \, but the pathways and molecules involved are largely unknown. Understand
 ing the language of inflammation is a central question in the field of Neu
 roimmunology and may guide new therapeutic approaches for multiple scleros
 is (MS) and other neurologic diseases. Interactions between CNS-resident c
 ells are highly heterogeneous\; astrocytes and microglia nourish and prote
 ct neurons\, while inflammatory subsets drive demyelination and neurodegen
 eration in neurologic diseases. We recently developed two novel approaches
  to study astrocyte-microglia interactions at the single-cell level during
  inflammation: 1) an in vivo barcoding-based strategy that analyzes the tr
 anscriptomes and connections between individual cells\, and 2) a droplet-b
 ased platform for genome-wide\, unbiased CRISPR/Cas9 screening of genes th
 at mediate cell crosstalk. In this seminar\, I will discuss the developmen
 t of these technologies and their application to study astrocyte-microglia
  signaling in experimental autoimmune encephalomyelitis (EAE)\, a preclini
 cal mouse model of MS.\n
DTSTART:20240220T210000Z
DTEND:20240220T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Microfluidic tools for studying cell-cell in
 teractions 
URL:/neuro/channels/event/killam-seminar-series-microf
 luidic-tools-studying-cell-cell-interactions-353656
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