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DESCRIPTION:The Feindel Virtual Brain and Mind Seminar presents 'Rare CNVs 
 and Phenome-wide Profiling: A tale of Divergence and Convergence' \n\nRegi
 stration available here.\n\nSpeaker: Jakub Kopal\n\nPostdoctoral Fellow\, 
 Department of Biomedical Engineering\, Faculty of Medicine\, and School of
  Computer Science\, ºÃÉ«TV\, Montreal\, QC\, Canada\n\nAbstract
 : Copy number variations (CNVs) are rare genomic disorders with consequenc
 es on the brain and behavior\, including a high risk for neuropsychiatric 
 illness. Polygenicity and pleiotropy imply that different CNVs converge on
  shared mechanisms at some level\, from genes to large-scale brain network
 s to the phenome. However\, isolated studies have investigated single CNV 
 loci at a time in small clinical samples. Consequently\, it remains unknow
 n why diverse CNVs increase the risk for the same developmental psychiatri
 c disorders. Here\, we dissected the impact on brain organization and beha
 vioral differentiation across 8 different CNV loci. We explored CNV-specif
 ic brain patterns distilled from multisite clinical samples. Further\, we 
 extensively annotated them with deep phenotyping through the UK Biobank. D
 espite causing disparate brain morphologies\, the 8 CNVs broadly agreed on
  the phenome-wide profiles across ~1000 lifestyle indicators. Our populati
 on-level confrontation established the structural divergences and phenotyp
 ical convergences of multi-gene mutations\, with direct relevance to major
  neuropsychiatric illness.\n\nBio: Jakub Kopal completed his Ph.D. in neur
 oscience under joint supervision from the University of Chemistry and Tech
 nology in Prague (Czech Republic) and Université Toulouse III – Paul Sabat
 ier (France) in 2021. In his thesis\, he focused on the role of connectivi
 ty in brain functioning. Currently\, he is working as a postdoctoral fello
 w at the intersection of neuroscience and genetics in the group of Danilo 
 Bzdok at ºÃÉ«TV and Sébastien Jacquemont at the University of M
 ontreal. His research interests include neuroscience\, data analysis\, and
  data visualization. Otherwise\, he enjoys pickles and random facts.\n\n\n
 The Feindel Virtual Brain and Mind (VBM) Seminar Series will advance the v
 ision of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1
 972–1984)\, to constantly bridge the clinical and research realms. The tal
 ks will highlight the latest advances and discoveries in neuropsychology\,
  cognitive neuroscience\, and neuroimaging.\n\nSpeakers will include scien
 tists from across The Neuro\, as well as colleagues and collaborators loca
 lly and from around the world. The series is intended to provide a virtual
  forum for scientists and trainees to continue to foster interdisciplinary
  exchanges on the mechanisms\, diagnosis and treatment of brain and cognit
 ive disorders.\n
DTSTART:20220413T200000Z
DTEND:20220413T210000Z
SUMMARY:Feindel Virtual Brain and Mind Lecture Series: Rare CNVs and phenom
 e-wide profiling: a tale of divergence and convergence
URL:/neuro/channels/event/feindel-virtual-brain-and-mi
 nd-lecture-series-rare-cnvs-and-phenome-wide-profiling-tale-divergence-338
 923
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