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UID:20250513T095931EDT-1554XdWzcx@132.216.98.100
DTSTAMP:20250513T135931Z
DESCRIPTION:La série Feindel Brain and Mind Seminar s’inscrit dans la ligne
  de pensée du Dr William Feindel (1918-2014)\, directeur du Neuro de 1972 
 à 1984\, qui consiste à maintenir un lien constant entre pratique clinique
  et recherche. Les présentations porteront sur les dernières avancées et d
 écouvertes en neuropsychologie\, en neurosciences cognitives et en neuro-i
 magerie. \n\nLes scientifiques du Neuro\, ainsi que des collègues et colla
 borateurs venus du milieu ou du monde entier\, se chargeront des conférenc
 es. Cette série se veut un forum virtuel pour les chercheurs et les stagia
 ires en vue de favoriser les échanges interdisciplinaires sur les mécanism
 es des troubles cérébraux et cognitifs\, leur diagnostic et leur traitemen
 t. \n\n\nPour assister en personne\, inscrivez-vous ici\n\nPour regarder v
 ia Vimeo\, cliquez ici\n\n\nLydia Chougar\n\nChercheuse postdoctorale\, Le
  Neuro\, Université ºÃÉ«TVl\n\nHôte: alain.dagher [at] mcgill.ca (Alain Dag
 her)\n\nAbstract: \n\nParkinson’s disease\, the second most common neurode
 generative disease after Alzheimer’s disease\, is the primary cause of Par
 kinsonism\, characterized by a combination of resting tremor\, rigidity\, 
 bradykinesia\, and postural instability. Atypical Parkinsonism refers to o
 ther rare neurodegenerative disorders\, such as progressive supranuclear p
 alsy (PSP)\, multiple system atrophy (MSA)\, and corticobasal degeneration
 \, which are associated with a poorer prognosis. Degeneration of the subst
 antia nigra pars compacta is the pathological hallmark of neurodegenerativ
 e Parkinsonian disorders. These diseases present significant challenges in
  terms of early diagnosis\, differentiation\, and understanding of their p
 athophysiology.\n\nOver the past twenty-five years\, neuroimaging has prof
 oundly transformed research and clinical management of Parkinsonism. Magne
 tic resonance imaging (MRI) provides several in vivo quantitative biomarke
 rs sensitive to various tissue properties that reveal underlying pathologi
 cal processes. Regional brain atrophy\, detected using T1-weighted three-d
 imensional (3D) sequences\, reflects neuronal loss. Diffusion anomalies in
 dicate the presence of microstructural alterations related to neuroinflamm
 ation\, while iron-sensitive imaging detects iron deposits. Neuromelanin-s
 ensitive MRI serves as a proxy for degeneration of the substantia nigra. M
 ore recently\, positron emission tomography (PET) has enabled the detectio
 n of misfolded protein aggregates\, such as Tau and alpha-synuclein\, seen
  in these diseases\, allowing for an ante-mortem pathological diagnosis.\n
 \nThe first part of the talk will illustrate how neuroimaging biomarkers c
 ontribute to a better understanding of the pathophysiology of Parkinson’s 
 disease and their use in providing an early diagnosis\, quantifying diseas
 e severity and progression\, and monitoring treatment effects. The second 
 part will highlight the contribution of neuroimaging to the differential d
 iagnosis of Parkinsonian disorders\, with a focus on recent applications o
 f machine learning algorithms trained with MRI features.\n\n \n
DTSTART:20240916T170000Z
DTEND:20240916T180000Z
LOCATION:De Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Seminar Series: Contribution of MRI to the U
 nderstanding and Diagnosis of Parkinsonism
URL:/neuro/fr/channels/event/feindel-brain-and-mind-se
 minar-series-contribution-mri-understanding-and-diagnosis-parkinsonism-359
 469
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