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DESCRIPTION:James Hanley\n\nProfessor | Department of Epidemiology\, Biosta
 tistics and Occupational Health\n	��ɫTV\n\nSupratik Roy\n\nLect
 urer in Statistics | Department of Statistics\n	University College Cork\, I
 reland\n\nWHEN: Wednesday\, November 22\, 2023\, from 3:30 to 4:30 p.m.\n
 \nWHERE: Hybrid | 2001 ��ɫTVl College\, Rm 1140 | Zoom &\n\nNote: Dr. J. H
 anley will present in-person & Dr. S. Roy will present from Ireland\n\nAbs
 tract\n\nAs for their “relative aetiological importance\,” Lionel Penrose'
 s analysis of “150 sibships\, containing each at least one” [child] with D
 own syndrome[...]\, “indicated that paternal age is not a significant fact
 or\, while maternal age is to be regarded as very important.” In hindsight
 \, his data analyses\, even with the help of Ronald Fisher\, seem rudiment
 ary. Moreover\, it appears that they were limited to the (2-D) 42 x 2 freq
 uency table of fathers' ages x Down/Normal children\, the corresponding 31
  x 2 table involving mothers' ages\, and the 42 x 31 table of fathers' age
 s x mothers' ages. These three marginal distributions\, derived from the t
 otal of 727 children\, were provided in the article.\n\nWe describe how\, 
 in what we think of as Statistical Sudoku\, we used linear programming\, a
 s well as the statistics reported in the text\, to reconstruct a full 3-D 
 42 x 31 x 2 frequency table describing the full joint distribution. We the
 n use these (non-unique) 3-D frequencies\, and a number of statistical met
 hods developed since 1933\, to re-consider Penrose's conclusions\, and to 
 draw some lessons re data disclosure.\n\nWe briefly mention how Fisher hel
 ped Penrose to then study the effects of maternal age and birth order.\n\n
 Speakers Bios\n\nDr. James Hanley: https://jhanley.biostat.mcgill.ca/\n	Dr.
  Supratik Roy: http://research.ucc.ie/profiles/D019/sroy\n
DTSTART:20231122T203000Z
DTEND:20231122T213000Z
SUMMARY:Prob [Down Syndrome | Parents' Ages]: Statistical Sudoku and Analys
 es of Penrose's Data  (J. Genetics 1933)
URL:/epi-biostat-occh/channels/event/prob-down-syndrom
 e-parents-ages-statistical-sudoku-and-analyses-penroses-data-j-genetics-19
 33-352739
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